Does it need re-setting of a computer if exchange the exhaust manifold?  
Since each sensor will work with STD computer and such as the value of A/F will not be changed, you can use it in comfort. At least exhaust manifold exchange can realize change of response and sound enough.
Moreover, there is also a setup of ECU about GDB. Although it was proved by IMPREZA magazine that a performance goes up at least ECU exchange, the further upgrade torque up can be felt by the synergistic effect with exhaust manifold.

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